Deubiquitinases (DUBs) play important roles in pathways that are dysregulated in cancer, such as DNA repair, cell growth, and apoptosis. USP7 or HAUSP (Herpesvirus-Associated Ubiquitin-Specific Protease) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.
Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP activity generally stabilizes its substrate proteins. This makes DUBs attractive potential drug targets for many cancers and neurodegenerative diseases. Ubiquitin-specific-processing proteases (USPs) are the largest class of DUBs.
Two new selective USP7 inhibitors GNE-6776 & GNE-6640 are now made available to the Research community.