Catalog Number: 4LSC1314
CAS #: 35661-51-9
Name: (9H-fluoren-9-yl)methyl hydrazinecarboxylate
Product Description: Building block used to perform aza-amino acid scan of peptide for probing the existence and importance of beta-turn conformations in bioactive peptides. This building block is useful to introduce aza-amino acid into a peptide chain using Fmoc chemistry thus is used to improve potency, selectivity and/or stability of a bioactive peptide.
Boeglin, D.; Lubell, W.D. Aza-Amino Acid Scanning of Secondary Structure Suited for Solid-Phase Peptide Synthesis with Fmoc Chemistry and Aza-Amino Acids with Heteroatomic Side Chains. J. Comb. Chem., 2005, 7 (6), pp 864–878. DOI: 10.1021/cc050043h
Boeglin , D.; Hamdan , F.F.; Melendez , R.E.; Cluzeau, J.; Laperriere, A.; Héroux, M. Bouvier, M. and Lubell W.D. Calcitonin Gene-Related Peptide Analogues with Aza and Indolizidinone Amino Acid Residues Reveal Conformational Requirements for Antagonist Activity at the Human Calcitonin Gene-Related Peptide 1 Receptor. J. Med. Chem., 2007, 50 (6), pp 1401–1408. DOI: 10.1021/jm061343w
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