4LSC1657 TEM1657 Octyl Isochlorogenamide A CAS# 2142000-38-0

Catalog #: 4LSC1657
CAS #: 2142000-38-0
Name: Octyl Isochlorogenamide A, TEM1657, STL1657, (2E,2’E)-((1R,2S,3R,5S)-2,5-dihydroxy-5-(octylcarbamoyl)cyclohexane-1,3-diyl) bis(3-(3,4-dihydroxyphenyl)acrylate).

In Stock !

 

TEM1657 formerly known as PAT1657, STL1657 or Octyl isochlorogenamide A is an hemi-synthetic compound having anti-inflammatory and cytoprotecting activities. Applied topically, it brings remarkable effects on psoriasis without side effects in preclinical models. The mechanism of action of TEM1657 uses the “Th17-dependant” pathway which is typical of widespread inflammatory pathologies such as Crohn’s disease or ulcerative colitis. These results suggest other potential applications for this drug candidate.

For TEM1657 analogs with improved physico-chemical properties and patentable structures, please contact us.

  • Molecular Formula: C33H41NO11
  • Molecular Weight: 627.69 g/mol
  • Specification: Minimum purity: 95.0 %

WO/2017/186779. Amide derivatives of polycaffeoylquinic acids, process for producing same and uses thereof. Damien Boeglin, Pierre Warnault.