4LSC1657 TEM1657 Octyl Isochlorogenamide A CAS# 2142000-38-0

Catalog #: 4LSC1657
CAS #: 2142000-38-0
Name: Octyl Isochlorogenamide A, TEM1657, STL1657, (2E,2’E)-((1R,2S,3R,5S)-2,5-dihydroxy-5-(octylcarbamoyl)cyclohexane-1,3-diyl) bis(3-(3,4-dihydroxyphenyl)acrylate).

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TEM1657 formerly known as PAT1657, STL1657 or Octyl isochlorogenamide A is an hemi-synthetic compound having anti-inflammatory and cytoprotecting activities. Applied topically, it brings remarkable effects on psoriasis without side effects in preclinical models. The mechanism of action of TEM1657 uses the “Th17-dependant” pathway which is typical of widespread inflammatory pathologies such as Crohn’s disease or ulcerative colitis. These results suggest other potential applications for this drug candidate.

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  • Molecular Formula: C33H41NO11
  • Molecular Weight: 627.69 g/mol
  • Specification: Minimum purity: 95.0 %

WO/2017/186779. Amide derivatives of polycaffeoylquinic acids, process for producing same and uses thereof. Damien Boeglin, Pierre Warnault.