4LSC2016 – UNC3866
Catalog Number: 4LSC2016
CAS #: 1872382-47-2 (free base) / 1872382-48-3 (TFA salt)
Name: UNC3866, methyl N2-(4-(tert-butyl)benzoyl)-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serinate.
Product Description: A cellular chemical probe targeting the chromodomains of Polycomb Repressive Complex 1. UNC3866, a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains.
Stuckey, J. I., Dickson, B. M., Cheng, N., Liu, Y., Norris, J. L., Cholensky, S. H., … Frye, S. V. (2016). A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology, 12(3), 180-187. DOI: 10.1038/nchembio.2007
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