4LSC2040 – WNK463
Catalog Number: 4LSC2040
CAS #: None
Name: N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)pyridin-2-yl)piperidin-4-yl)-1H-imidazole-5-carboxamide, WNK463
Molecular Formula: C21H24F3N7O2
Molecular Weight: 463.46 g/mol
Minimum purity: 95.0 %
4LSC2040 (WNK463) is a the first orally bioavailable pan-WNK-kinase inhibitor that exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and
electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology.
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