4LSC2179 PF-06446846 – 1632250-49-7
Catalog Number: 4LSC2179
CAS #: 1632250-49-7 (free base), 1632250-50-0 (hydrochloride salt)
Name: (R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide, PF-06446846
Molecular Formula: C22H20ClN7O
Molecular Weight: 433.9 g/mol
Minimum purity: 95.0 %
4LSC2179 (PF-06446846) is a PCSK9 translation inhibitor. PF-06446846 is highly selective for the inhibition of PCSK9 translation. The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.
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