4LSC2543 [d6]-Ribociclib CAS# 1328934-40-2

Catalog Number: 4LSC2543
CAS #: 1328934-40-2
Related CAS #: 1211441-98-3 (unlabeled)
Name: [d6]-Ribociclib, [d6]-LEE-011, [d6]-NVP-LEE011, [d6]-TK8ERE8P56, 7-cyclopentyl-N,N-bis(methyl-d3)-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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Ribociclib is an inhibitor of cyclin D1/CDK4 and CDK6, and is used for the treatment of certain kinds of breast cancer. It is also being studied as a treatment for other drug-resistant cancers. 

 Stable isotope labeled Ribociclib is intended for use as an internal standard for the quantification of Ribociclib by LC or GC-mass spectrometry.

If the number, nature and/or location of stable isotope label atoms (D, 15N, 13C) in this molecule don’t fit with your application, don’t hesitate to contact us to discuss your specific needs.

Keywords:

Stable isotope labeled active pharmaceutical ingredient (API), stable isotope dilution analysis, internal standard, stable isotope labeled standard (SIL), therapeutic drug monitoring (TDM), quantitative bioanalytical method validation, clinical diagnosis, LC/MS method validation, diagnostic breath test, clinical chemistry, diagnostic tools & biomarkers.

  • Molecular Formula: C23H24D6N8O
  • Molecular Weight: 440.59 g/mol
  • Specification:
    Minimum chemical purity: 95.0 %
    Minimum Isotopic Enrichment: 2H ≥98 %
  • Solubility: Dimethylsulfoxide (DMSO), Methanol (MeOH)
  • Packing size: 1mg, 10mg, 25mg, 50mg, 100mg
  • HS Code: 284590

Development and validation of LC-MS/MS methods for the measurement of ribociclib, a CDK4/6 inhibitor, in mouse plasma and Ringer’s solution and its application to a cerebral microdialysis study. Kala et al. 2017, Journal of Chromatography B, 1057:110-117. doi: 10.1016/j.jchromb.2017.05.002


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