4LSC2543 [d6]-Ribociclib CAS# 1328934-40-2
Catalog Number: 4LSC2543
CAS #: 1328934-40-2
Related CAS #: 1211441-98-3 (unlabeled)
Name: [d6]-Ribociclib, [d6]-LEE-011, [d6]-NVP-LEE011, [d6]-TK8ERE8P56, 7-cyclopentyl-N,N-bis(methyl-d3)-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Ribociclib is an inhibitor of cyclin D1/CDK4 and CDK6, and is used for the treatment of certain kinds of breast cancer. It is also being studied as a treatment for other drug-resistant cancers.
Stable isotope labeled Ribociclib is intended for use as an internal standard for the quantification of Ribociclib by LC or GC-mass spectrometry.
If the number, nature and/or location of stable isotope label atoms (D, 15N, 13C) in this molecule don’t fit with your application, don’t hesitate to contact us to discuss your specific needs.
Stable isotope labeled active pharmaceutical ingredient (API), stable isotope dilution analysis, internal standard, stable isotope labeled standard (SIL), therapeutic drug monitoring (TDM), quantitative bioanalytical method validation, clinical diagnosis, LC/MS method validation, diagnostic breath test, clinical chemistry, diagnostic tools & biomarkers.
- Molecular Formula: C23H24D6N8O
- Molecular Weight: 440.59 g/mol
Minimum chemical purity: 95.0 %
Minimum Isotopic Enrichment: 2H ≥98 %
- Solubility: Dimethylsulfoxide (DMSO), Methanol (MeOH)
- Packing size: 1mg, 10mg, 25mg, 50mg, 100mg
- HS Code: 284590
Development and validation of LC-MS/MS methods for the measurement of ribociclib, a CDK4/6 inhibitor, in mouse plasma and Ringer’s solution and its application to a cerebral microdialysis study. Kala et al. 2017, Journal of Chromatography B, 1057:110-117. doi: 10.1016/j.jchromb.2017.05.002
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