4LSC2543 [d6]-Ribociclib CAS# 1328934-40-2

Ribociclib is an inhibitor of cyclin D1/CDK4 and CDK6, and is used for the treatment of certain kinds of breast cancer. It is also being studied as a treatment for other drug-resistant cancers. 

 Stable isotope labeled Ribociclib is intended for use as an internal standard for the quantification of Ribociclib by LC or GC-mass spectrometry.

If the number, nature and/or location of stable isotope label atoms (D, ¹⁵N, ¹³C) in this molecule don’t fit with your application, don’t hesitate to contact us to discuss your specific needs.

Keywords:

Stable isotope labeled active pharmaceutical ingredient (API), stable isotope dilution analysis, internal standard, stable isotope labeled standard (SIL), therapeutic drug monitoring (TDM), quantitative bioanalytical method validation, clinical diagnosis, LC/MS method validation, diagnostic breath test, clinical chemistry, diagnostic tools & biomarkers.

• Molecular Formula: C₂₃H₂₄D₆N₈O
  
• Molecular Weight: 440.59 g/mol
• Specification:
  Minimum chemical purity: 95.0 %
  Minimum Isotopic Enrichment: ²H ≥98 %
• Solubility: Dimethylsulfoxide (DMSO), Methanol (MeOH)
• Packing size: 5mg, 10mg, 25mg, 50mg, 100mg
• HS Code: 284590

Development and validation of LC-MS/MS methods for the measurement of ribociclib, a CDK4/6 inhibitor, in mouse plasma and Ringer’s solution and its application to a cerebral microdialysis study. Kala et al. 2017, Journal of Chromatography B, 1057:110-117. doi: 10.1016/j.jchromb.2017.05.002