4LSC2562 – 1675201-83-8

SKU: 4LSC2562 Category: Tags: ,

Catalog Number: 4LSC2562

CAS #: 1675201-83-8

Name: (S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid

Molecular Formula: C29H33NO5

Molecular Weight: 475.59 g/mol

Specification: Minimum purity: 95.0 %

Product Description: 4LSC2562 is a s a small molecule inhibitor of PD-1/PD-L1 (Programmed Death-1/Programmed Death-Ligand 1) interaction. 4LSC2562 blocks the interaction of programmed cell death protein 1 (PD-1, CD279) with its ligand protein (PD-L1, CD274). In preliminary studies, PD-1/PD-L1 inhibitor 1 blocks this interaction with an IC50 value between 6 and 100 nM, as assessed by a HTRF (homogenous time-resolved fluorescence) binding assay.

References: US2016/0194307 A1 – Compounds useful as immunomodulators

 

 

 


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