4LSC2868 THAL-SNS-032 CAS# 2139287-33-3

Catalog Number: 4LSC2868
CAS #: 2139287-33-3
Name: THAL-SNS-032, N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide

THAL-SNS-032 is a selective CDK9 degrader consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

  • Molecular Formula: C40H52N8O10S2
  • Molecular Weight: 869.02 g/mol
  • Specification: Minimum purity: 95.0 %

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Olson et al., 2018, Nature Chemical Biology volume 14, 163–170. doi: 10.1038/nchembio.2538