4LSC2870 CU-CPT8m CAS# 125079-83-6

Catalog Number: 4LSC2870
CAS #: 125079-83-6
Name: CU-CPT8m, 7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis, osteoarthritis and Still’s disease, a rare autoimmune illness.

CU-CPT8m  has a Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity; shows no effect on TLR1/2/6, TLR3, TLR4, TLR5, TLR7 and TLR9; inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells with IC50 of 90 nM, also abolishes the elevation of TNF-α and IL-8 mRNA levels; suppresses the proinflammatory cytokine production in multiple human primary cells derived from different patients.

  • Molecular Formula: C14H12N4O
  • Molecular Weight: 252.28 g/mol
  • Specification: Minimum purity: 95.0 %

Small-molecule inhibition of TLR8 through stabilization of its resting state. Zhang et al., 2018, Nature Chemical Biology volume 14, 58–64. doi: 10.1038/nchembio.2518