4LSC2871 CU-CPT9b CAS# 2162962-69-6
Catalog Number: 4LSC2871
CAS #: 2162962-69-6
Name: CU-CPT9b, 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol
CU-CPT9b is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity; shows no significant inhibition for other TLRs at 1 uM in cellular assays; consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer.
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