4LSC2871 CU-CPT9b CAS# 2162962-69-6

Catalog Number: 4LSC2871
CAS #: 2162962-69-6
Name: CU-CPT9b, 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol

CU-CPT9b is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity; shows no significant inhibition for other TLRs at 1 uM in cellular assays; consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer.

  • Molecular Formula: C16H13NO2
  • Molecular Weight: 251,28 g/mol
  • Specification: Minimum purity: 95.0 %

Small-molecule inhibition of TLR8 through stabilization of its resting state. Zhang et al., 2018, Nature Chemical Biology volume 14, 58–64. doi: 10.1038/nchembio.2518