4LSC2880 [13C5,15N]-MMAE / [13C5,15N]-Monomethyl auristatin E

Catalog #: 4LSC2880
CAS #: N/A
Related CAS #: 474645-27-7 (unlabeled)
Name: [13C5,15N]-MMAE, [13C5,15N]-Monomethyl auristatin E

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent, a very potent anti-mitotic agent that inhibits cell division by blocking the polymerisation of tubulin. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (mAB) which directs it to the cancer cells.

Stable isotope labeled MMAE is intended for use as an internal standard for the quantification of MMAE by LC/MS.

If the number, nature and/or location of stable isotope label atoms (D, 15N, 13C) in this molecule don’t fit with your application, don’t hesitate to contact us to discuss your specific needs.

Keywords:

Stable isotope labeled active pharmaceutical ingredient (API),  stable isotope dilution analysis, internal standard, stable isotope labeled standard (SIL), therapeutic drug monitoring (TDM), quantitative bioanalytical method validation, clinical diagnostic, LC/MS method validation, ADCs cytotoxin.

  • Molecular Formula: C3413C5H67N415NO7
  • Molecular Weight: 723.95 g/mol
  • Specification:
    Minimum purity: 95.0 %
    Minimum Isotopic Enrichment: 15N ≥98 %, 13C ≥99 %
  • Solubility: Methanol (MeOH), Dimethylsulfoxide (DMSO),
  • HS Code: 284590

N/A


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