4LSC2881 [D8]-MMAE / [D8]-Monomethyl auristatin E

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent, a very potent anti-mitotic agent that inhibits cell division by blocking the polymerisation of tubulin. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (mAB) which directs it to the cancer cells.

Stable isotope labeled MMAE is intended for use as an internal standard for the quantification of MMAE by LC/MS.

If the number, nature and/or location of stable isotope label atoms (D, ¹⁵N, ¹³C) in this molecule don’t fit with your application, don’t hesitate to contact us to discuss your specific needs.

Keywords:

Stable isotope labeled active pharmaceutical ingredient (API),  stable isotope dilution analysis, internal standard, stable isotope labeled standard (SIL), therapeutic drug monitoring (TDM), quantitative bioanalytical method validation, clinical diagnostic, LC/MS method validation, ADCs cytotoxin.

• Molecular Formula: C₃₉H₅₉D₈N₅O₇
• Molecular Weight: 726.04 g/mol
• Specification:
  Minimum purity: 95.0 %
  Minimum Isotopic Enrichment: ²H ≥97 %
• Solubility: Methanol (MeOH), Dimethylsulfoxide (DMSO),
• HS Code: 284590

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