Sphingosines
Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.
Major activities:
- Apoptosis induction
- Mitogenic
- Involved in cell proliferation
- Invovlved in Gene expression
- Binding of factor VII to tissue factor
- Binding of Thyrotropic releasing factor to its recepetor
- Enzyme inhibitor including: Protein kinase C (specific), Phosphotidate hydrolase, Na+, K+ ATPase, Phosphocholine cytidyl transferase, Calmodulin dependant enzymes
- Ca ion mobilization and Ca ion mediated cell regulation process
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Molecular Formula: C18H37NO2
- Molecular Weight: 299.5 g/mol
- Specification:
- Purity: >95% (TLC, HPLC)
- Aspect: White powder
- Long time storage: -18°C
Packed under inert gas, shipped at sub zero temperature