4LSC3318 Sphingosine (d18:1) CAS# 123-78-4

Catalog Number: 4LSC3318
CAS #: 123-78-4
Name: D-erythro-Sphingosine C-18 base, Sphingosine (d18:1)

Sphingosines

Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.

Major activities:

  • Apoptosis induction
  • Mitogenic
  • Involved in cell proliferation
  • Invovlved in Gene expression
  • Binding of factor VII to tissue factor
  • Binding of Thyrotropic releasing factor to its recepetor
  • Enzyme inhibitor including: Protein kinase C (specific), Phosphotidate hydrolase, Na+, K+ ATPase, Phosphocholine cytidyl transferase, Calmodulin dependant enzymes
  • Ca ion mobilization and Ca ion mediated cell regulation process
  • Molecular Formula:  C18H37NO2

  • Molecular Weight: 299.5 g/mol
  • Specification:
    • Purity: >95% (TLC, HPLC)
    • Aspect: White powder
  • Long time storage: -18°C
Packed under inert gas, shipped at sub zero temperature