Sphingosines

Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.

Major activities:

• Apoptosis induction
• Mitogenic
• Involved in cell proliferation
• Invovlved in Gene expression
• Binding of factor VII to tissue factor
• Binding of Thyrotropic releasing factor to its recepetor
• Enzyme inhibitor including: Protein kinase C (specific), Phosphotidate hydrolase, Na+, K+ ATPase, Phosphocholine cytidyl transferase, Calmodulin dependant enzymes
• Ca ion mobilization and Ca ion mediated cell regulation process

• Molecular Formula:  C₁₈H₃₇NO₂

• Molecular Weight: 299.5 g/mol
• Specification:
  • Purity: >95% (TLC, HPLC)
  • Aspect: White powder
• Long time storage: -18°C