4LSC3322 N,N-Dimethyl-D-erythro-Sphingosine (d18:1) CAS# 119567-63-4

Catalog Number: 4LSC3322
CAS #: 119567-63-4
Name: N,N-Dimethyl-D-erythro-Sphingosine, (2S,3R,E)-2-(dimethylamino)octadec-4-ene-1,3-diol


N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 µM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.

Major activities:

  • Competitive inhibitor of Sphingosine kinase and Sphingosine-1-phosphate synthesis
  • Induction of EGP autophosphorylation
  • Induction of apoptosis in human leukemia HL-60 cells
  • Activator of Sphingosine dependant kinase (SDK 1 )
  • Inhibition of Selectins
  • Enhance SRC Kinase activity
  • Affects signaling in cancer cells potent tumor growth by induction differentiation
  • Intracellular stores
    • Molecular Formula:  C20H41NO2

    • Molecular Weight: 327.55 g/mol
    • Specification:
      • Purity: >98% (TLC, HPLC)
      • Aspect: Colorless to off-white oil
    • Long time storage: -18°C
    • Solubility: DMSO, EtOH, Chloroform

Packed under inert gas, shipped at sub zero temperature. Colorless oil solidifying at sub zero temperature.