5′- & 3′- Spacer Modifiers

Spacer modifiers are designed for internal and 5′-modifications. Spacer C-9 and spacer C-18 phosphoramidite are polyethyleneglycol-based that can be added sequentially when a longer arm is required. dSpacer allows the introduction of an abasic site into oligonucleotides. Spacer C-3 has an aliphatic linker.

• Molecular Formula:  C₃₃H₄₃N₂O₅P

• Molecular Weight: 578.7 g/mol
• Specification:
  • HPLC – Identity is confirmed by comparison with a reference sample, Minimum purity
  • NMR – Purity is determined by ³¹P NMR and isomeric purity is veified by ¹H NMR
  • Coupling Test – Coupling efficiency > 98%
  • Solution Test – 0.1M solution clear and free of particulate contamination
  • Loss on drying – volatile components are determined to be < 2%
  • Water content – determined to be < 0.4%
  • Certificate of Analysis are available for every batch, even for long past delivered products.