4LSC3432 [d5]-Phosphatidylethanol / [d5]-PEth 16:0/18:1 CAS# 1612140-92-7

Catalog Number: 4LSC3432
CAS #: 1612140-92-7
Related CAS #: 1612140-88-1 (unlabeled)
Name: [d5]-Phosphatidylethanol, [d5]-PEth 16:0/18:1, ammonium (R)-ethyl-d5 (2-(oleoyloxy)-3-(palmitoyloxy)propyl) phosphate

Phosphatidyl ethanol (PEth) is an abnormal phospholipid formed in the erythrocyte membrane exclusively in the presence of ethanol. It is described as exhibiting a high diagnostic sensitivity and specificity for detecting active chronic excessive drinking behaviors. It may also be useful for characterizing the drinking pattern (i.e. identifying binge drinking episodes) and differentiating light-moderate drinking from abstinence.

 Stable isotope labeled PEth is intended for use as an internal standard for the quantification of PEth by LC or GC-mass spectrometry.

If the number, nature and/or location of stable isotope label atoms (D, 15N, 13C) in this molecule don’t fit with your application, don’t hesitate to contact us to discuss your specific needs.

Keywords:

Stable isotope labeled active pharmaceutical ingredient (API), stable isotope dilution analysis, internal standard, stable isotope labeled standard (SIL), therapeutic drug monitoring (TDM), quantitative bioanalytical method validation, clinical diagnosis, LC/MS method validation, diagnostic breath test, clinical chemistry, diagnostic tools & biomarkers.

  • Molecular Formula: C39H73D5NO8P
  • Molecular Weight: 725.06 g/mol
  • Specification:
    Minimum chemical purity: 95.0 %
    Minimum Isotopic Enrichment: 2H ≥98 %
  • Solubility: chlorofom (CHCl3) /methanol (MeOH)
  • Packing size: 5, 10, 25, 50mg, custom packing size on request
  • HS Code: 284590
Alcohol biomarkers are physiological indicators of alcohol exposure or ingestion and may reflect the presence of an alcohol use disorder” Substance Abuse Treatment Advisory. Sept 2006, Vol 5, Issue 4 .
 
Quantification of phosphatidylethanol 16:0/18:1, 18:1/18:1, and 16:0/16:0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers. N. Kummer and al. Analytical and Bioanalytical Chemistry 2015, 408(3).  doi: 10.1007/s00216-015-9169-1
 
Phosphatidylethanol (PEth) as a Biomarker of Alcohol Consumption in HIV-Infected Young Russian Women: Comparison to Self-Report Assessments of Alcohol Use. A.K. Littlefield and al. AIDS Behav. 2017, 21(7):1938-1949.
doi: 10.1007/s10461-017-1769-7

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