4LSC3551 PF-06747711 CAS# 1892576-58-7
Catalog #: 4LSC3551
CAS #: 1892576-58-7
Name: 3-cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, PF-06747711
PF-06747711 is a potent, selective, and orally bioavailable Retinoic Acid Receptor-
Related Orphan Receptor C2 Inverse Agonist (RORC2). It has been found to have the ability to reduce IL-17 levels and skin inflammation in a preclinical in vivo animal model upon oral administration.
- Molecular Formula: C26H26F3N5O2
- Molecular Weight: 497.52 g/mol
- Specification: Minimum purity: 95.0 %
Discovery of 3‑Cyano‑N‑(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-
(trifluoromethyl)‑1H‑pyrrolo[2,3‑b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-
Related Orphan Receptor C2 Inverse Agonist. M.E. Schnute and al. J.Med.Chem, ASAP, 2018. doi: 10.1021/acs.jmedchem.8b00392
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