4LSC3646 JMV2894 CAS# 925238-66-0
Catalog Number: 4LSC3646
CAS #: 925238-66-0 (free base)
Related CAS #: 956489-49-9 (Trifluoroacetate salt)
Name: JMV2894, (R)-N-(1-(5-(2-(1H-indol-3-yl)ethyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)piperidine-4-carboxamide
JMV2894 is a 1, 2, 4-triazole derived Growth Hormone Secretagogue (GHS) that acts as a potent ghrelin receptor (GHS-R1a) full agonist (IC50=0.5 nM in a binding assay, EC50=0.6nM in an intracelullar Ca2+ release assay). JMV2894 has been shown to accelerate body mass recovery and protect skeletal muscle in experimental model of cachexia.
- Molecular Formula: C37H41N7O3
- Molecular Weight: 631.78 g/mol
- Specification: Minimum purity: 95.0 %
JMV2894, a novel Growth Hormone Secretagogue, accelerates body mass recovery in an experimental model of cachexia. Endocrine. Elena Bresciani et al., 2017, Endocrine, 58(1):106-114. doi: 10.1007/s12020-016-1184-2
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia. Elena Conte et al., 2017, Journal of Cachexia, Sarcopenia and Muscle; 8: 386–404. doi: 10.1002/jcsm.12185
Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia. Giuseppe Sirago et al., 2017, Scientific Reports, 7:13017. doi: 10.1038/s41598-017-13504-y
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