4LSC379 – D159687
Catalog Number: 4LSC379
CAS #: 1155877-97-6
Name: 1-(4-((3′-chloro-6-methoxy-[1,1′-biphenyl]-3-yl)methyl)phenyl)urea, D159687, P-378
Molecular Formula: C21H19ClN2O2
Molecular Weight: 366.85 g/mol
Minimum purity: 95.0 %
4LSC379 (D159687) is a small-molecule allosteric modulators of PDE4D that do not completely inhibit enzymatic activity (Imax ~ 80–90%). It has reduced potential to cause emesis, a dose-limiting side effect of existing active site–directed PDE4 inhibitors, while maintaining biological activity in cellular and in vivo models.
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